Applicability of models for carrier‐mediated serotonin transport to pools of serotonin in intact human platelets.
Year: 1981
Type: article
Abstract: Intact human platelets can accumulate serotonin (5HT) in compartments which are vesicular (thrombin-releasable) or extra-vesicular (non-thrombin-releasable). 1. The net accumulation of extracellular 5HT in either compartment is not coupled in a reciprocal fashion to the presence of appropriate sodium gradients across the cell plasma membrane, and 5HT already present in either compartment is not removed when trans-membrane sodium gradients are abolished or reversed. 2. Net counter-transport of 5HT in either compartment is not detectable. 3. The data are not consistent with transport models such as that for glucose in which appropriate sodium gradients produce gradients of a co-transported molecule, or with models in which counter-transport can occur.
Source: The Journal of Physiology
Authors: J L Costa, D L Murphy, H Stark
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2014682525