Work

A Fungal Nonribosomal Peptide Synthetase Module that can Synthesize Thiopyrazines

Year: 2011

Type: article

Abstract: A nonribosomal peptide synthetase-like enzyme (NRPS325) from Aspergillus terreus was reconstituted in vitro and was shown to synthesize thiopyrazines using an unprecedented mechanism. Substrate promiscuity of NRPS325 toward different amino acids and free thiols was explored to produce >60 different thiopyrazine compounds.

Source: Organic Letters

DOI: 10.1021/ol200288w

Authors: Kangjian Qiao, Hui Zhou, Wei Xu, Wenjun Zhang, Neil Garg, Yi Tang

Institution: University of California, Los Angeles

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: California Institute of Technology, National Institute of General Medical Sciences

Awards: G1832550329, G2554635287