Work

Measurement of the traction force of biological cells by digital holography

Year: 2011

Type: article

Abstract: The traction force produced by biological cells has been visualized as distortions in flexible substrata. We have utilized quantitative phase microscopy by digital holography (DH-QPM) to study the wrinkling of a silicone rubber film by motile fibroblasts. Surface deformation and the cellular traction force have been measured from phase profiles in a direct and straightforward manner. DH-QPM is shown to provide highly efficient and versatile means for quantitatively analyzing cellular motility.

Source: Biomedical Optics Express

DOI: 10.1364/boe.3.000153

Authors: Xiao Yu, Michael Cross, Changgeng Liu, David C. Clark, Donald T. Haynie, Myung K. Kim

Institution: University of South Florida

Language: English

Topic: Digital Holography and Microscopy

Subfield: Atomic and Molecular Physics, and Optics

Field: Physics and Astronomy

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,913

Funder: National Science Foundation