Work

Translation of RNAIII, the Staphylococcus aureus agr regulatory RNA molecule, can be activated by a 3′-end deletion

Year: 1995

Type: article

Abstract: RNAIII, an RNA molecule shown to encode delta-hemolysin and independently to regulate toxin synthesis in Staphylococcus aureus, is transcribed at the mid-exponential phase of growth, while its target genes are activated 2 h later, at the post-exponential phase of growth. We show here that the translation of RNAIII to the 26-amino acid peptide delta-hemolysin is delayed by 1 h, and that this delay is abolished when the 3'-end of this molecule is deleted. We suggest that structural changes of RNAIII to a translatable form of the molecule precede its regulation of target gene expression.

Source: FEMS Microbiology Letters

DOI: 10.1016/0378-1097(95)00356-a

Authors: Naomi Balaban, Richard P. Novick

Institutions: University of California, Davis, NYU Langone Health

Language: English

Topic: Bacterial Genetics and Biotechnology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: Federation of European Microbiological Societies, U.S. Public Health Service, National Institute of Allergy and Infectious Diseases

Award: G2113527428