Shortened Radiation Therapy Schedules for Early-Stage Breast Cancer: A Review of Hypofractionated Whole-Breast Irradiation and Accelerated Partial Breast Irradiation
Year: 2014
Type: article
Abstract: Breast-conserving therapy consisting of segmental mastectomy followed by whole-breast irradiation (WBI) has become widely accepted as an alternative to mastectomy as a treatment for women with early-stage breast cancer. WBI is typically delivered over the course of 5-6 weeks to the whole breast. Hypofractionated whole-breast irradiation and accelerated partial breast irradiation have developed as alternative radiation techniques for select patients with favorable early-stage breast cancer. These radiation regimens allow for greater patient convenience and the potential for decreased health care costs. We review here the scientific rationale behind delivering a shorter course of radiation therapy using these distinct treatment regimens in this setting as well as an overview of the published data and pending trials comparing these alternative treatment regimens to WBI.
Source: The Breast Journal
DOI: 10.1111/tbj.12232
Institutions: The University of Texas MD Anderson Cancer Center, Rutgers, The State University of New Jersey, Rutgers Cancer Institute, Virginia Commonwealth University, Summa Health System, University of Pennsylvania, Willis-Knighton Cancer Center, Allegheny General Hospital, Michigan Healthcare Professionals
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2015028387