Work

Two-state flashing molecular pump

Year: 2009
Type: article
Abstract: Here we study a pumping device capable of maintaining a density gradient and a flux of particles across a membrane. Its driving mechanism is based on the flashing ratchet effect powered by the random telegraph process in the presence of thermal fluctuations. Unlike Brownian motors, the concentrations at both reservoir boundaries need to be implemented as boundary conditions. The residence transition rates of the dichotomic flashing are related to the binding and hydrolysis of ATP molecules. The model is exactly solved and explored. The pump energetics is discussed and the relevant parameter values are tuned within a biological scale.
Language: English
Open Access status: bronze
OpenAlex ID: W2015065633
FWCI: 1.145
Cites: 23
Cited by: 12
Related to: 10