Work

Mitochondrial permeability transition and oxidative stress

Year: 2001

Type: review

Abstract: Mitochondrial permeability transition (MPT) is a non-selective inner membrane permeabilization that may precede necrotic and apoptotic cell death. Although this process has a specific inhibitor, cyclosporin A, little is known about the nature of the proteinaceous pore that results in MPT. Here, we review data indicating that MPT is not a consequence of the opening of a pre-formed pore, but the consequence of oxidative damage to pre-existing membrane proteins.

Source: FEBS Letters

DOI: 10.1016/s0014-5793(01)02316-x

Authors: Alicia J. Kowaltowski, Roger F. Castilho, Anibal E. Vercesi

Institutions: Universidade de São Paulo, Universidade Estadual de Campinas (UNICAMP)

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Fundação de Amparo à Pesquisa do Estado de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico