Work

Antibodies against phosphorylcholine are not altered in plasma of patients with Alzheimer’s disease

Year: 2015

Type: article

Abstract: BACKGROUND: Phosphorylcholine is one of the major epitopes of oxidised low density lipoprotein. Low levels of IgM antibodies against phosphorylcholine (anti-PC) are associated with development of myocardial infarction and stroke. It has been shown that patients with Alzheimer's disease and other dementias have significantly lower serum anti-PC levels compared to controls, suggesting that low levels of atheroprotective anti-PC may play a role in AD and dementia. METHODS: We quantified levels of anti-PC levels using an ELISA in plasma from 176 controls, 125 patients with Alzheimer's disease, 19 patients with vascular dementia and 63 patients with other dementias. RESULTS: We observed similar plasma anti-PC levels in controls, patients with Alzheimer's disease, and other dementias. CONCLUSIONS: Our data suggests that anti-PC is not useful as a biomarker for Alzheimer's disease.

Source: BMC Neurology

DOI: 10.1186/s12883-015-0260-1

Authors: Edina Silajdžić, Maria Björkqvist, Oskar Hansson

Institutions: Lund University, Skåne University Hospital

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,090