Work

Potent selective inhibitors of protein kinase C

Year: 1989

Type: article

Abstract: A series of potent, selective inhibitors of protein kinase C has been derived from the structural lead provided by the microbial broth products, staurosporine and K252a. Our inhibitors block PCK in intact cells (platelets and T cells), and prevent the proliferation of mononuclear cells in response to interleukin 2 (IL2).

Source: FEBS Letters

DOI: 10.1016/0014-5793(89)81494-2

Authors: Peter D. Davis, Christopher H. Hill, Elizabeth Keech, Geoffrey Lawton, John S. Nixon, Anthony D. Sedgwick, Julie Wadsworth, Donald Westmacott, Sandra E. Wilkinson

Institution: Roche (United Kingdom)

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2015648136

FWCI: 7.861

Cites: 17

Cited by: 477

Related to: 10