Work

Aberrant B-cell homeostasis in chronic GVHD

Year: 2015

Type: article

Abstract: Recent studies have compelled further interest in the potential pathological role of B cells in chronic graft-versus-host disease (cGVHD). In patients with cGVHD, B cells are activated and primed for survival via B-cell activating factor and B-cell receptor-associated pathways. Understanding the signaling pathways that drive immune pathology in cGVHD will facilitate the development of new strategies to selectively target aberrantly activated B cells and restore normal B-cell homeostasis after allogeneic stem cell transplantation.

Source: Blood

DOI: 10.1182/blood-2014-12-567834

Authors: Stefanie Sarantopoulos, Jerome Ritz

Institutions: Duke University, Duke Cancer Institute, Harvard University, Dana-Farber Cancer Institute

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute