Work

Inhibition of N-acetylaspartate production

Year: 1996

Type: article

Abstract: The effect of specific irreversible inhibitors of complexes I, III, IV and V of the mitochondrial respiratory chain, (rotenone, myxothiazol, cyanide and oligomycin, respectively) on mitochondrial N-acetylaspartate production, and its relationship to oxidative phosphorylation (ATP production and oxygen consumption) were investigated in isolated rat brain mitochondria. Mitochondrial N-acetylaspartate production, ATP production and oxygen consumption were all significantly decreased in the presence of each of the inhibitors used compared with control incubations, and correlated positively with each other. It is postulated that decreased N-acetylaspartate levels seen in disease states by 1H NMR spectroscopy in vivo may reflect primarily an impaired mitochondrial energy production rather than neuronal cell loss.

Source: Neuroreport

DOI: 10.1097/00001756-199605310-00014

Authors: Timothy E. Bates, Maria Strangward, Julie Keelan, Gavin P. Davey, Peter M. G. Munro, John B. Clark

Institutions: University of London, UCL Queen Square Institute of Neurology, University College London

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4297162325

FWCI: 2.533

Cites:

Cited by: 442

Related to: 10