Work

Host Genetic Control of Recovery From Friend Leukemia Virus-induced Splenomegaly

Year: 1974

Type: article

Abstract: The influence of the major mouse histocompatibility gene complex (H-2) on the response of mice to Friend leukemia virus was studied in F(1) congenic mice differing only at genes within the H-2 complex. F(1) mice which were H-2(b/b) had a high incidence of recovery from splenomegaly compared to H-2(b/d) or H-2(b/a) mice. In mice with recombinations within the H-2 complex a gene (designated RFV-1), responsible for the Friend virus recovery effect, was found to map near or within the D region of serologically detectable transplantation antigens. Because the incidence of recovery was much higher in F(1)H-2(b/b) mice than in parental H-2(b/b) mice, other non-H-2 host genetic factors also appear to be important to expression of recovery in H-2(b/b) F(1) mice. The mechanisms of action of these genes remain unknown.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.140.6.1457

Authors: Bruce Chesebro, Kathy Wehrly, Jack Stimpfling

Institutions: National Institutes of Health, United States Public Health Service, National Institute of Allergy and Infectious Diseases, McLaughlin Research Institute, Rocky Mountain Laboratories

Language: English

Topic: T-cell and Retrovirus Studies

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2015821234

FWCI: 3.71

Cites: 30

Cited by: 171

Related to: 10