Work

Quantitative imaging of magnetization transfer using multiple selective pulses

Year: 1999

Type: article

Abstract: New spectroscopic and imaging methods have been developed for quantitatively measuring magnetization transfer (MT). These methods use trains of radiofrequency (rf) pulses with pulse separations much longer than 1/k(mf) and pulse durations much shorter than 1/k(mf), where k(mf) is the rate of MT from the immobile (macromolecular) protons to the mobile (free water) protons. Signal sensitivity to MT occurs when these pulses affect the mobile and immobile proton pools to different degrees. The signal from water may be quantitatively related to the macromolecular content of the sample using theory. The method has been used to make quantitative measurements of macromolecular content in cross-linked bovine serum albumin and employed in conjunction with echoplanar imaging to produce maps of the spatial distribution of the macromolecular content.

Source: Magnetic Resonance in Medicine

DOI: 10.1002/(sici)1522-2594(199905)41:5<1065::aid-mrm27>3.0.co;2-9

Authors: Daniel F. Gochberg, Richard P. Kennan, Matthew D. Robson, John C. Gore

Institution: Yale University

Language: English

Topic: Advanced MRI Techniques and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

Funder: National Cancer Institute

Awards: G5215627085, PROTON RELAXATION AND CONTRAST MECHANISMS IN MRI