Work

Nicord® Expanded Hematopoietic Progenitor Cells (HPC) Are Capable of Outcompeting the Unmanipulated (UM) Cord Blood Unit and of Prolonged Myeloid and Lymphoid Engraftment Following Myeloablative Dual Umbilical Cord Blood (UCB) Transplantation

Year: 2013

Type: article

Abstract: Human transplantation of expanded HPCs resulting in durable, robust donor myeloid and T-cell engraftment has yet to be reported. A pilot study of myeloablative dual UCB transplantation where one UCB unit is expanded ex vivo using NiCord technology has completed accrual. The NiCord UCB graft consisted of an expanded CD133+ and an unexpanded CD133- T-cell fraction. HPCs were expanded for 21 days in media containing cytokines supplemented with nicotinamide (NAM). All patients were conditioned with TBI (1350cGy), fludarabine 160mg/m2 ±cyclophosphamide 120mg/kg (n=2).

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2012.11.044