Year: 2009
Type: review
Abstract: Analysis of genome and expressed sequence tag data bases at the turn of the millennium unveiled a new protease family named the type II transmembrane serine proteases (TTSPs) in a Journal of Biological Chemistry minireview (Hooper, J. D., Clements, J. A., Quigley, J. P., and Antalis, T. M. (2001) J. Biol. Chem. 276, 857-860). Since then, the number of known TTSPs has more than doubled, and more importantly, our understanding of the physiological functions of individual TTSPs and their contribution to human disease has greatly increased. Progress has also been made in identifying molecular substrates and endogenous inhibitors. This minireview summarizes the current knowledge of the rapidly advancing TTSP field.
Source: Journal of Biological Chemistry
Authors: Thomas H. Bugge, Toni M. Antalis, Qingyu Wu
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
Awards: G1634533506, Vascular Remodeling by Membrane Serine Proteases, G4276995960, The cardiac protease corin in natriuretic peptide processing and hypertension, New Function for the Serpin PAI-2 as a Regulator of pRb, Protease Pathways in the Gastrointestinal Tract, NEW FUNCTION SERPIN PAI 2 AS A REGULAR OF RB, G7650110720, UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANT
OpenAlex ID: W2016021454