Work

Radiosensitization of prostate cancer by priming the wild-type p53-dependent cellular senescence pathway

Year: 2007

Type: article

Abstract: A dramatic stage-migration in diagnosis of prostate cancer has led to earlier detection of clinically localized carcinoma and an increased use of radiation therapy. The p53 protein responds to irradiation-induced DNA damage by removing critically damaged cells from the proliferative pool. This review will focus on the dominant role that p53-dependent cellular senescence, rather than cell death, plays in determining the radiosensitivity of human prostate cancer cells in vitro. The finding that senescence is a primary mechanism of tumor regression indicates that p53 activators or downstream effectors may prove effective in radiosensitizing some carcinoma of the prostate.

Source: Cancer Biology & Therapy

DOI: 10.4161/cbt.6.8.4544

Authors: Brian D. Lehmann, James A McCubrey, David M. Terrian

Institution: East Carolina University

Language: English

Topic: Telomeres, Telomerase, and Senescence

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Public Health Service, National Cancer Institute