Work

Eukaryotic regulatory RNAs: an answer to the ‘genome complexity’ conundrum

Year: 2007

Type: preprint

Abstract: A large portion of the eukaryotic genome is transcribed as noncoding RNAs (ncRNAs). While once thought of primarily as "junk," recent studies indicate that a large number of these RNAs play central roles in regulating gene expression at multiple levels. The increasing diversity of ncRNAs identified in the eukaryotic genome suggests a critical nexus between the regulatory potential of ncRNAs and the complexity of genome organization. We provide an overview of recent advances in the identification and function of eukaryotic ncRNAs and the roles played by these RNAs in chromatin organization, gene expression, and disease etiology.

Source: Genes & Development

DOI: 10.1101/gad.1484207

Authors: Kannanganattu V. Prasanth, David L. Spector

Institution: Cold Spring Harbor Laboratory

Language: English

Topic: Cancer-related molecular mechanisms research

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

Funders: Institute for Molecular Bioscience, University Of Queensland, National Institute of General Medical Sciences

Awards: G1378631638, G7280018357