Work

Activation-flow coupling with forepaw stimulation in female and male rats

Year: 1999

Type: article

Abstract: Activation-flow coupling (AFC), the coupling of changes in cerebral blood flow (CBF) with neuronal function, is the basis for many functional neuroimaging techniques. Prior studies have shown that females have higher cerebral blood flow levels than males and that estrogen may affect the mediators involved in AFC. No studies have compared AFC responses between males and females. We assessed the AFC responses to forepaw stimulation using signal-averaged laser Doppler (LD) measurements of CBF in alpha-chloralose anesthetized female and male rats. Results for various stimulus parameters were similar for both sexes except at 2 Hz where females had a higher blood flow response. These results suggest that the AFC responses in males and females are similar, but require further validation in humans.

Source: Neuroscience Research

DOI: 10.1016/s0168-0102(99)00065-6

Authors: Beau M Ances, Joel H Greenberg, John A Detre

Institution: University of Pennsylvania

Language: English

Topic: Optical Imaging and Spectroscopy Techniques

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,770