Year: 2000
Type: article
Abstract: (summarized by Margaret Stull and Rachata Lumkul) The use of umbilical cord blood (UCB) for hematopoietic stem cell transplantation has recently received great attention due to the possibility of increased engraftment potential and decreased incidence of graft versus host disease (GVHD) for UCB, as compared to bone marrow (BM). Indeed, several studies have suggested that UCB may be an enriched source of hematopoietic stem cells. In 1992, the New York Blood Center initiated the Placental Blood Project, through which UCB units are collected from healthy newborns at Mt. Sinai Hospital. The phase I trial using the banked UCB for transplant grafts began five years ago as a collaboration between Dr. Kurtzberg's group at Duke University and Dr. John Wagner's group at The University of Minnesota. In this trial, researchers are attempting to determine the efficacy of banked partially mismatched UCB in hematopoietic stem cell transplants. Concerns in performing unrelated UCB transplants include the number of cells that can be harvested and the feasibility of using this procedure in adults, the limits of HLA mismatch, GVHD incidence and severity, and graft versus leukemia (GVL) effects.
Source: Stem Cells
Authors: J. Kurtzberg, P. Martin, N. Chao, C. Stevens, P. Rubinstein
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2016315439