Mapping cerebellar degeneration in HIV/AIDS
Year: 2008
Type: article
Study design: Observational Study
Abstract: Progressive brain atrophy in HIV/AIDS is associated with impaired psychomotor performance, perhaps partly reflecting cerebellar degeneration; yet little is known about how HIV/AIDS affects the cerebellum. We visualized the three-dimensional profile of atrophy in 19 HIV-positive patients (age: 42.9+/-8.3 years) versus 15 healthy controls (age: 38.5+/-12.0 years). We localized consistent patterns of subregional atrophy with an image analysis method that automatically deforms each patient's scan, in three dimensions, to match a reference image. Atrophy was greatest in the posterior cerebellar vermis (14.9% deficit) and correlated with depression severity (P=0.009, corrected), but not with dementia, alcohol/substance abuse, CD4+T-cell counts, or viral load. Profound cerebellar deficits in HIV/AIDS (P=0.007, corrected) were associated with depression, suggesting a surrogate disease marker for antiretroviral trials.
Source: Neuroreport
Authors: Andrea D. Klunder, Ming-Chang Chiang, Rebecca A. Dutton, Sharon E. Lee, Arthur W. Toga, Oscar L. Lopez, Howard J. Aizenstein, James T. Becker, Paul M. Thompson
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: G130320643, G1757829149, G2483494913, Algorithms to Map Disease &Genetic Effects on the Brain, G3489163652, Novel PDEs for Cortical Mapping and Analysis in Disease, G3642348494, UCLA Alzheimer's Disease Research Center, A Multidimensional Alzheimer's Disease Brain Atlas, G6644087359, NATURAL HISTORY OF DEMENTIA, Age Moderates HIV-Related CNS Dysfunction
OpenAlex ID: W2016353904