A genome-wide meta-analysis of nodular sclerosing Hodgkin lymphoma identifies risk loci at 6p21.32
Year: 2011
Type: review
Study design: Observational Study
Abstract: Nodular sclerosing Hodgkin lymphoma (NSHL) is a distinct, highly heritable Hodgkin lymphoma subtype. We undertook a genome-wide meta-analysis of 393 European-origin adolescent/young adult NSHL patients and 3315 controls using the Illumina Human610-Quad Beadchip and Affymetrix Genome-Wide Human SNP Array 6.0. We identified 3 single nucleotide polymorphisms (SNPs) on chromosome 6p21.32 that were significantly associated with NSHL risk: rs9268542 (P = 5.35 × 10(-10)), rs204999 (P = 1.44 × 10(-9)), and rs2858870 (P = 1.69 × 10(-8)). We also confirmed a previously reported association in the same region, rs6903608 (P = 3.52 × 10(-10)). rs204999 and rs2858870 were weakly correlated (r(2) = 0.257), and the remaining pairs of SNPs were not correlated (r(2) < 0.1). In an independent set of 113 NSHL cases and 214 controls, 2 SNPs were significantly associated with NSHL and a third showed a comparable odds ratio (OR). These SNPs are found on 2 haplotypes associated with NSHL risk (rs204999-rs9268528-rs9268542-rs6903608-rs2858870; AGGCT, OR = 1.7, P = 1.71 × 10(-6); GAATC, OR = 0.4, P = 1.16 × 10(-4)). All individuals with the GAATC haplotype also carried the HLA class II DRB1*0701 allele. In a separate analysis, the DRB1*0701 allele was associated with a decreased risk of NSHL (OR = 0.5, 95% confidence interval = 0.4, 0.7). These data support the importance of the HLA class II region in NSHL etiology.
Source: Blood
Authors: Wendy Cozen, Dalin Li, Timothy Best, David J. Van Den Berg, Pierre-Antoine Gourraud, Victoria K. Cortessis, Andrew D. Skol, Thomas M. Mack, Sally L. Glaser, Lawrence M. Weiss, Bharat N. Nathwani, Smita Bhatia, Fredrick R. Schumacher, Christopher K. Edlund, Amie E. Hwang, Susan L. Slager, Zachary S. Fredericksen, Louise C. Strong, Thomas M. Habermann, Brian K. Link, James R. Cerhan, Leslie L. Robison, David V. Conti, Kenan Onel
Institutions: University of Southern California, USC Norris Comprehensive Cancer Center, University of Chicago, University of California, San Francisco, University of California San Francisco Medical Center, Cancer Prevention Institute of California, Stanford Medicine, Stanford University, City Of Hope National Medical Center, Cedars-Sinai Medical Center, Mayo Clinic, The University of Texas MD Anderson Cancer Center, University of Iowa, University of Iowa Health Care, St. Jude Children's Research Hospital
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1225814147, Etiology of Alkylator-Induced Myeloid Leukemia, G2016980950, #14: Residual Tissue Repository to Create HIV Cancer Tumor Tissue Microrarrays , G2925750098, G3174164616, G3272408970, G4444553339, G5201190111, G523178288, G592384189, G6622425196, G6811731727, G7046539232, G7278087418, G7384296583, G7507271246, Rapid Response Surveillance Study #09-5 - Constructing Geographic Areas in GIS fo, G8824031917, EPIDEMIOLOGY OF HD IN TWINS--INFECTIONS/T-CELL FUNCTION
OpenAlex ID: W2016455091