Year: 2011
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: We have previously reported evidence of an inverse association between a urinary F(2)-isoprostane and type 2 diabetes risk in a pilot case-control study nested within the Insulin Resistance Atherosclerosis Study (IRAS). Here, we report the results from the study extended to the entire IRAS cohort. RESEARCH DESIGN AND METHODS: This prospective study included 138 incident type 2 diabetes case and 714 noncase subjects. Four F(2)-isoprostanes (iPF2α-III; 2,3-dinor-iPF2α-III; iPF2α-VI; and 8,12-iso-iPF2α-VI) were assayed in baseline urine samples using liquid chromatography-tandem mass spectrometry. RESULTS: Three F(2)-isoprostanes showed significant inverse associations with type 2 diabetes risk: the adjusted odds ratios were 0.52 (95% CI 0.39-0.67), 0.56 (0.42-0.73), 0.62 (0.48-0.79), and 0.91 (0.72-1.12) for iPF2α-III; 2,3-dinor-iPF2α-III; iPF2α-VI; and 8,12-iso-iPF2α-VI, respectively. CONCLUSIONS: Our findings indicate that urinary F(2)-isoprostanes are inversely associated with type 2 diabetes risk beyond the traditional risk factors and may be useful in identifying high-risk populations.
Source: Diabetes Care
DOI: 10.2337/dc11-1502
Authors: Dora Il'yasova, Ivan Spasojevic, Karel Base, Haoyue Zhang, Frances Wang, Sarah P. Young, David S. Millington, Ralph B. D’Agostino, Lynne E. Wagenknecht
Language: English
Subfield: Biochemistry
Domain: Life Sciences
Open Access status: hybrid
Awards: G133225849, G2799744797, G9000146748
OpenAlex ID: W2016514524