Work

Short Communication: Methamphetamine Treatment Increases in Vitro and in Vivo HIV Replication

Year: 2009

Type: article

Abstract: To delineate the mechanistic basis for the epidemiological association between methamphetamine use and accelerated progression to AIDS, we evaluated the direct in vitro and in vivo effects of methamphetamine on HIV-1 replication. Methamphetamine administration significantly increased HIV-1 production by both HIV-infected monocytes and CD4 T lymphocytes in vitro. In addition, in vivo methamphetamine treatment increased HIV production and viremia in mice transgenic for a replication-competent HIV provirus and human cyclin T1. Methamphetamine activated transcription of the HIV long terminal repeat (LTR) regulatory region, was associated with nuclear translocation of NF-kappaB. Our results provide further insights into the mechanisms by which methamphetamine accelerates disease course in HIV-infected individuals.

Source: AIDS Research and Human Retroviruses

DOI: 10.1089/aid.2008.0282

Authors: Sima Shelly Toussi, Aviva Joseph, Jian Hua Zheng, Monica Dutta, Laura Santambrogio, Harris Goldstein

Institution: Albert Einstein College of Medicine

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, Center for AIDS Research, University of Washington, National Institute of Allergy and Infectious Diseases