Work

Simple assay to screen for inhibitors of interaction between the human immunodeficiency virus envelope glycoprotein and its cellular receptor, CD4

Year: 1992

Type: article

Abstract: The binding of the human immunodeficiency virus envelope glycoprotein gp120 to the CD4 molecule is the initial step in the viral replicative cycle. This interaction is therefore an important target for therapeutic intervention for the treatment of human immunodeficiency virus infection. We designed an enzyme-linked immunosorbent assay which detects the interaction between recombinant soluble forms of CD4 and gp160. This assay could be used as an initial screen of libraries of synthetic chemical compounds and natural products.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.36.2.267

Authors: V Chams, T Idziorek, P J Maddon, D Klatzmann

Institutions: Centre National de la Recherche Scientifique, Pitié-Salpêtrière Hospital

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2016669505

FWCI:

Cites: 26

Cited by: 2

Related to: 10