Plasma prolactin level and risk of incident hypertension in postmenopausal women
Year: 2010
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Laboratory and cross-sectional human studies suggest a potential role for prolactin in the pathogenesis of hypertension; however, the prospective association between prolactin and hypertension has not been previously reported. METHODS: We prospectively examined the association between daytime plasma prolactin levels and the risk of incident hypertension among 874 postmenopausal women who were participants of the Nurses' Health Study. Cox proportional hazards regression models were used to adjust for potential confounders. RESULTS: We identified 183 incident cases of hypertension during 8 years of follow-up. After adjusting for potential confounders, the relative risk of hypertension for a 1-standard deviation higher plasma prolactin was 1.31 (95% confidence interval 1.05-1.62). Compared with women with plasma prolactin levels of 8.0 ng/ml or below, the multivariable relative risk of incident hypertension for those with prolactin levels above 8.0 ng/ml was 1.34 (95% confidence interval 0.90-1.99). CONCLUSION: A higher daytime plasma prolactin level is independently associated with an increased risk of incident hypertension among postmenopausal women.
Source: Journal of Hypertension
Authors: Luxia Zhang, Gary C Curhan, John P Forman
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2016674335