Year: 2007
Type: article
Abstract: In this study, the neurovascular coupling relationship was noninvasively studied in the human visual cortex. Graded neuronal/hemodynamic suppression conditions were generated using a paired-stimulus paradigm. Visual evoked potential was measured to quantify neuronal activity. Hemodynamic activities were measured and quantified by perfusion and blood oxygenation level-dependent changes. All quantification was normalized to the same activation condition induced by a single stimulus paradigm within each experimental session. This experiment design eliminated the confounding factors such as anesthesia and inconsistent neurovascular coupling patterns within and/or among tasks. The results reveal that (i) there is a tight neurovascular coupling at graded neuronal suppression conditions; (ii) the neurovascular coupling relationship contains a subtle, but significant, nonlinear component; and (iii) the linear model, nevertheless, is still a good approximation reflecting the neurovascular coupling relationship. This study extends the range of the neurovascular coupling relationship from graded neuronal excitation conditions to graded neuronal suppression conditions.
Authors: Nanyin Zhang, Zhongming Liu, Bin He, Wei Chen
Institution: University of Minnesota
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G1441323675, High Resolution EEG Source Imaging: Validation Study, Novel RF Coils for In Vivo MR Applications at High Field, ITR: High-Resolution Cortical Imaging of Brain Electrical Activity, PROBING FAST NEURONAL INTERACTION USING FUNCTIONAL MRI, G4233162539, Study of Brain Oxidative Metabolism by 17-0 imaging, G5334669364, FUNCTIONAL MRI MAPPING OF HUMAN THALAMOCORTICAL NETWORKS, NMR Imaging and Spectroscopy, G6596748690, G8407103733, G8419436335, G8440405544, Neuroscience Cores For MR Studies of the Brain
OpenAlex ID: W2016747092