Work

Lenalidomide induces degradation of IKZF1 and IKZF3

Year: 2014

Type: article

Abstract: Lenalidomide and its analogs, thalidomide and pomalidomide, specifically inhibit growth of mature B-cell lymphomas, including multiple myeloma, and induce interleukin-2 (IL-2) release from T cells. We recently found that this results from activation of the CRBN-CRL4 E3 ubiquitin ligase to degrade the lymphoid transcription factors IKZF1 (Ikaros) and IKZF3 (Aiolos).

Source: OncoImmunology

DOI: 10.4161/21624011.2014.941742

Authors: Jan Krönke, Slater N Hurst, Benjamin L Ebert

Institution: Brigham and Women's Hospital

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913