Work

Cardiac and neuroprotection regulated by α1-adrenergic receptor subtypes

Year: 2011

Type: review

Abstract: Sympathetic nervous system regulation by the α(1)-adrenergic receptor (AR) subtypes (α(1A), α(1B), α(1D)) is complex, whereby chronic activity can be either detrimental or protective for both heart and brain function. This review will summarize the evidence that this dual regulation can be mediated through the different α(1)-AR subtypes in the context of cardiac hypertrophy, heart failure, apoptosis, ischemic preconditioning, neurogenesis, locomotion, neurodegeneration, cognition, neuroplasticity, depression, anxiety, epilepsy, and mental illness.

Source: Journal of Receptors and Signal Transduction

DOI: 10.3109/10799893.2010.550008

Authors: Dianne M. Perez, Van A. Doze

Institutions: Cleveland Clinic, Cleveland Clinic Research, University of North Dakota

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Heart, Lung, and Blood Institute