Work

Characterization and application of the Fe(ii) and α-ketoglutarate dependent hydroxylase FrbJ

Year: 2011

Type: article

Abstract: The Fe(II) and α-ketoglutarate-dependent hydroxylase FrbJ was previously demonstrated to utilize FR-900098 synthesizing a second phosphonate FR-33289. Here we assessed its ability to hydroxylate other possible substrates, generating a library of potential antimalarial compounds. Through a series of bioassays and in vitro experiments, we identified two new antimalarials.

Source: Chemical Communications

DOI: 10.1039/c1cc13597j

Authors: Matthew A. DeSieno, Wilfred A. van der Donk, Huimin Zhao

Institutions: University of Illinois Urbana-Champaign, Carl R. Woese Institute for Genomic Biology

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: Discovery, Design, and Development of Phosphonic Acid Antibiotics, Training Program at the Chemistry-Biology Interface, G755578399