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The geometric and spatial constraints of the microenvironment induce oligodendrocyte differentiation

Year: 2008

Type: article

Abstract: The oligodendrocyte precursor cell (OPC) arises from the subventricular zone (SVZ) during early vertebrate development to migrate and proliferate along axon tracts before differentiating into the myelin-forming oligodendrocyte. We demonstrate that the spatial and temporal regulation of oligodendrocyte differentiation depends intimately on the axonal microenvironment and the density of precursor cells along a specified axonal area. Differentiation does not require dynamic axonal signaling, but instead is induced by packing constraints resulting from intercellular interactions. Schwann cells and even artificial beads bound to the axonal surface can mimic these constraints and promote differentiation. Together, these results describe the coordinately controlled biophysical interaction of oligodendrocyte precursors within an axonal niche leading to self-renewal and differentiation.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.0805640105

Authors: Sheila S. Rosenberg, Eve E. Kelland, Eleonora Tokar, Asia R. De La Torre, Jonah R. Chan

Institution: University of Southern California

Language: English

Topic: Neurogenesis and neuroplasticity mechanisms

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

Funders: National Multiple Sclerosis Society, Christopher and Dana Reeve Foundation, Multiple Sclerosis Society, National Institutes of Health

OpenAlex ID: W2017042997

FWCI: 2.074

Cites: 36

Cited by: 243

Related to: 10