HER2/neu: an increasingly important therapeutic target. Part 2: Distribution of HER2/neu overexpression and gene amplification by organ, tumor site and histology
Year: 2014
Type: article
Abstract: No biological molecule in the field of oncology has been more extensively or more successfully targeted for therapeutic intent than the product of the c-erbB2 gene, HER2/neu.This is the second of a comprehensive three-part review of the foundation for and therapeutic targeting of HER2/neu.The distribution of HER2/neu overexpression and/or gene amplification by individual tumor sites and histologies will be comprehensively surveyed and described.This provides a bridge between the primarily basic science focused Part I, and the survey of clinical applications to follow in Part III.In combination, this comprehensive survey will identify opportunities and promising areas for future evaluation of HER2/neu-targeted therapies, highlighting the importance of HER2/neu as an increasingly important therapeutic target.
Source: Clinical Investigation
DOI: 10.4155/cli.14.62
Author: Edward L Nelson
Institution: University of California, Irvine
Language: English
Topic: HER2/EGFR in Cancer Research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2017054633