Alvaradoins E−N, Antitumor and Cytotoxic Anthracenone C-Glycosides from the Leaves of Alvaradoa haitiensis
Year: 2007
Type: article
Abstract: Bioactivity-directed fractionation of an extract of the leaves of Alvaradoa haitiensis, using the KB (human oral epidermoid carcinoma) cell line, led to the isolation and identification of 10 new anthracenone C-glycosides, alvaradoins E-N (1-10), along with the known compound chrysophanol (11). The cytotoxicity of all compounds was evaluated, and preliminary structure-activity relationships are suggested. The most potent compounds in the in vitro assays (1 and 2) were evaluated in vivo versus the P388 (murine lymphocytic leukemia) model, and alvaradoin E (1) showed antileukemic activity (125% T/C) at a dose of 0.2 mg kg-1 per injection when administered intraperitoneally.
Source: Journal of Natural Products
DOI: 10.1021/np070005a
Authors: Sharnelle S. Phifer, Dongho Lee, Eun-Kyoung Seo, Nam-Cheol Kim, Tyler N. Graf, David J. Kroll, Hernán A. Navarro, Robert A. Izydore, Francisco Jiménez, Ricardo Garcia, William C. Rose, Craig R. Fairchild, Robert Wild, Djaja D. Soejarto, Norman R. Farnsworth, A. Douglas Kinghorn, Nicholas H. Oberlies, Monroe E. Wall, Mansukh C. Wani
Institutions: North Carolina Central University, RTI International
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: green
Funder: National Cancer Institute
Awards: G2791146328, G87161865
OpenAlex ID: W2017071668