Work

Tolerance after Solid Organ and Hematopoietic Cell Transplantation

Year: 2012

Type: review

Abstract: Solid organ transplantation (SOT) and hematopoietic cell transplantation (HCT) have developed over the past 5 decades largely independent from each other despite sharing biologic principles, an almost identical repertoire of immunosuppressive (IS) drugs, and biologic response modifiers to overcome barriers of immune rejection between host and donor. Long-term graft function and recipient survival are the same primary endpoints for SOT and HCT. It is remarkable that allogeneic tissues can exhibit physiologic function in a host environment that may display disparate HLA antigens, blood type, and other immune response molecules.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2011.11.005

Authors: Paul Szabolcs, William J. Burlingham, Angus W. Thomson

Institutions: Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, University of Wisconsin–Madison, University of Pittsburgh

Language: English

Topic: Transplantation: Methods and Outcomes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650