Work

Genetic Modification of T Cells

Year: 2010

Type: article

Abstract: Adoptively transferred T cells have shown activity in treating viral infections after hemopoietic transplantation and anti-tumor activity against some malignancies such as melanoma and lymphoma. Current research focuses on defining the optimum type of cell for transfer to improve persistence and genetically modifying infused T cells to augment function, overcome tumor evasion strategies and allow ablation should adverse effects occur.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2010.09.019

Authors: Chiara Bonini, Malcolm K. Brenner, Helen E. Heslop, Richard A. Morgan

Institutions: IRCCS Ospedale San Raffaele, Houston Methodist, Baylor College of Medicine, Texas Children's Hospital, National Cancer Institute

Language: English

Topic: CAR-T cell therapy research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650