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Left atrial size is independently associated with cognitive function

Year: 2013
Type: article
Study design: Observational Study
Abstract: Left atrial (LA) diameter is easily attainable from echocardiograph and sensitive to underlying cardiovascular disease severity, although its association with neurocognitive outcomes is not well understood. Fifty older adults (64.50 ± 9.41 years), recruited from outpatient cardiology clinics and local papers who underwent magnetic resonance imaging, were administered the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and completed psychosocial self-report measures. LA diameter was quantified using echocardiogram. Hierarchical regression analyses revealed that greater LA size was independently associated with reduced performance on the following RBANS composites: language, delayed memory, and total index (p < 0.05 for all). Hierarchical regression analysis demonstrated no significant association between LA diameter and whole brain volume (p > 0.05). The current study suggests that greater LA size is associated with cognitive dysfunction in older adults and prospective studies are needed to validate these findings and elucidate underlying mechanisms.
DOI: 10.3109/00207454.2013.774396
Authors: Michael L. Alosco, John Gunstad, Beth A. Jerskey, Uraina S. Clark, Jason J. Hassenstab, Xiaomeng Xu, Athena Poppas, Ronald A. Cohen, Lawrence H. Sweet
Institutions: Kent State University, Summa Health System, Summa Akron City Hospital, Brown University, Washington University in St. Louis, Miriam Hospital, Rhode Island Hospital, University of Florida Health, University of Florida, University of Georgia
Language: English
Field: Medicine
Open Access status: green
Awards: G1116577514, Age Effects on HIV-associated Brain Dysfunction, G41511347, G6109780786, HEART DISEASE, CNS DYSFUNCTION &OUTCOME IN THE ELDERLY, G8166832892, University of Florida Older Americans Independence Center (OAIC)
OpenAlex ID: W2017213473
FWCI: 0.212
Cites: 83
Cited by: 24
Related to: 10