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A primate-specific microRNA enters the lung cancer landscape

Year: 2013

Type: article

Abstract: Characterization of the lung cancer genome through unbiased next-generation sequencing has led to the discovery of new driver somatic mutations (1, 2) and gene fusions (3). Lung cancers show the second highest prevalence of somatic mutations among all cancer types, and a mutation profile that reflects the effect of chronic exposure to tobacco carcinogens, the main risk factor etiologically associated with this disease (2⇓–4). The next chapter of genomic decoding, through small RNA sequencing, brings about the discovery of primate-specific microRNAs (miRNAs) of the airway epithelium and the intriguing possibility that some may function as lung tumor suppressors (5).

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.1318740110

Authors: Ana I. Robles, Curtis C. Harris

Institutions: National Institutes of Health, National Cancer Institute, Center for Cancer Research

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institutes of Health