Work

Improved Conditions for the Proline-Catalyzed Aldol Reaction of Acetone with Aliphatic Aldehydes

Year: 2014

Type: article

Abstract: The proline-catalyzed asymmetric aldol reaction between aliphatic aldehydes and acetone has, to date, remained underdeveloped. Challenges in controlling this reaction include avoiding undesired side reactions such as aldol condensation and self-aldolization. In recent years we have developed optimized conditions, which enable high yields and good to excellent enantioselectivities, and which are presented in this communication.

Source: Synlett

DOI: 10.1055/s-0033-1340919

Authors: Benjamin List, Alberto Martínez, Kristina Zumbansen, Arno Döhring, Manuel van Gemmeren

Institution: Max-Planck-Institut für Kohlenforschung

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funder: Max-Planck-Gesellschaft

OpenAlex ID: W2017281138