Work

Legume cyclotides shed light on the genetic origin of knotted circular proteins

Year: 2011

Type: article

Abstract: Fast, low-cost, accurate detection of time-resolved dynamic nucleic acid conformational variation in response to small molecule binding: 1) enriches our understanding of nucleic acid structure, and regulation of structure by small molecules as ...Nucleic acids can undergo conformational changes upon binding small molecules. These conformational changes can be exploited to develop new therapeutic strategies through control of gene expression or triggering of cellular responses and can also be used ...

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.1107849108

Author: Julio A. Camarero

Institution: University of Southern California

Language: English

Topic: Biochemical and Structural Characterization

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: U.S. Department of Defense, National Institutes of Health, National Institute of General Medical Sciences

Awards: G4526143277, Cell-based screening and selection of cyclotide-based capture reagents for protei, G9000212401