Work

Stress, symmetry, and psoriasis: Possible role of neuropeptides

Year: 1986

Type: article

Abstract: The role of stress as a triggering factor in the exacerbation of psoriasis and the clinically symmetric distribution of psoriatic plaques suggested a possible role for neuropeptides in the etiopathogenesis of psoriasis. Several observations by other investigators involving substance P suggested to us a possible role for substance P as a modulator of the inflammatory response in psoriasis. A hypothesis for the role of substance P that would account for the temporal onset with stress, the clinical symmetry of lesions, and the histopathologic features of psoriasis is presented.

Source: Journal of the American Academy of Dermatology

DOI: 10.1016/s0190-9622(86)70034-0

Authors: Eugene M. Farber, Brian J. Nickoloff, Bernard Recht, Jorma E. Fraki

Institutions: Stanford Medicine, Stanford University

Language: English

Topic: Psoriasis: Treatment and Pathogenesis

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,200