Get started
Work

Genomic Profiling of Hormone-Naïve Lymph Node Metastases in Patients with Prostate Cancer

Year: 2006
Type: article
Study design: Observational Study
Abstract: The progression of organ-confined prostate cancer to metastatic cancer is inevitably fatal. Consequently, identification of structural changes in the genome and associated transcriptional responses that drive this progression is critical to understanding the disease process and the development of biomarkers and therapeutic targets. In this study, whole genome copy number changes in genomes of hormone-naïve lymph node metastases were profiled using array comparative genomic hybridization, and matched primaries were included for a subset. Matched primaries and lymph node metastases showed very similar copy number profiles that are distinct from primary tumors that fail to metastasize.
Source: Neoplasia
DOI: 10.1593/neo.06421
Authors: Pamela L. Paris, Matthias D. Hofer, Giancarlo Albo, Rainer Kuefer, Juergen E. Gschwend, Richard E. Hautmann, Jane Fridyland, Jeffrey Simko, Peter R. Carroll, Mark A. Rubin, Colin Collins
Institutions: University of California, San Francisco, University of California San Francisco Medical Center, Brigham and Women's Hospital, Harvard University, University of Bari Aldo Moro, University Hospital Ulm
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $3,530
OpenAlex ID: W2017435063
FWCI: 2.93
Cites: 23
Cited by: 24
Related to: 10