Work

How to Train Your Dragon: Targeted Delivery of MicroRNA to Cancer Cells In Vivo

Year: 2014

Type: article

Abstract: The fundamental role of microRNAs (miRNAs) in both initiation and progression of cancer has made them attractive therapeutic targets.1 miRNAs can simultaneously alter expression of multiple target genes and often disrupt entire signaling networks, resulting in efficient changes in the activity and phenotype of target cells. At the same time, their broad functionality can be a liability that results in difficult-to-control off-target effects and toxicities. A report by Esposito et al. in this issue of Molecular Therapy provides a possible solution to the problem of cell-specific delivery of therapeutic miRNAs and represents an important step in the development of targeted miRNA mimics.

Source: Molecular Therapy

DOI: 10.1038/mt.2014.73

Authors: Marcin Kortylewski, Sergey Nechaev

Institutions: City Of Hope National Medical Center, Beckman Research Institute

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500