Effect of HAART on Incident Cancer and Noncancer AIDS Events Among Male HIV Seroconverters
Year: 2008
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To explore the impact of highly active antiretroviral therapy (HAART) on the prevention of AIDS-defining cancers relative to other AIDS-defining events. DESIGN: Prospective cohort study using 2,121 HIV+ male seroconverters (median age: 28 years, 51% white/non-Hispanic) in the Tri-Service AIDS Clinical Consortium (n = 1694) and the Multicenter AIDS Cohort Study (n = 427). METHODS: Poisson regression models, with calendar periods to represent antiretroviral therapy, were extended to analyze first incident AIDS-defining cancers and other first AIDS-defining events as competing risks. RESULTS: Eighty-one AIDS-defining cancers (64 Kaposi sarcomas; 17 non-Hodgkin lymphomas) and 343 other AIDS events occurred during 14,483 person-years in 1990-2006. The rate ratio of AIDS-defining cancers during the HAART calendar period was 0.26 (95% confidence limits: 0.15, 0.46) and of other AIDS-defining events was 0.28 (95% confidence limits: 0.21, 0.36) compared with the monotherapy/combination therapy calendar period, adjusting for age, infection duration, race, and cohort. The association of HAART with decreased AIDS incidence seemed to be equal (interaction ratio = 0.95 (95% confidence limits: 0.51, 1.74) for AIDS-defining cancers and other AIDS-defining events. CONCLUSIONS: In human immunodeficiency virus-infected men, HAART seems equally protective against first AIDS-defining cancers and other first AIDS-defining events.
Institutions: Johns Hopkins University, Walter Reed National Military Medical Center, Naval Medical Center San Diego, Uniformed Services University of the Health Sciences, Northwestern University, Wilford Hall Ambulatory Surgical Center, United States Air Force, University of California, Los Angeles, University of Pittsburgh
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1474614938, G1648982045, GENERAL CLINICAL RESEARCH CENTER, G2017072594, G2221715304, G344188330, G359857122, Natural History of AIDS in Homosexual Men, MULTICENTER AIDS COHORT STUDY PATHOGENESIS RESEARCH, G51363488, University of Pittsburgh Multicenter AIDS Cohort Study (MACS), Center/Coordination, Analysis and Management/MACS, G6120741853, MULTICENTER AIDS COHORT STUDY PATHOGENESIS RESEARCH LABS, Multicenter AIDS Cohort Study, G714446084, The Kidney Disease in Children Data Management and Analysis Center (KIDMAC), Multicenter AIDS Cohort Study - Part B (Baltimore Center), Institutional Research Cancer Epidemiology Fellowship
OpenAlex ID: W2017728485