Mini‐review: Transendothelial migration of leukocytes: through the front door or around the side of the house?
Year: 2004
Type: review
Abstract: Leukocyte adhesion to the endothelial cells lining the vessel wall and the subsequent migration of the leukocytes into the underlying tissue are key elements of both innate and adaptive immunity. Leukocyte extravasation is generally believed to take place through small gaps at intercellular endothelial cell junctions -- the paracellular route. This view has, however, been repeatedly challenged by morphological studies demonstrating leukocyte migration through the endothelial cells themselves -- the transcellular pathway. On the basis of the current experimental evidence, we propose consideration that both pathways are equally possible for a leukocyte's journey from the apical surface of the endothelium to its basal side.
Source: European Journal of Immunology
Authors: Britta Engelhardt, Hartwig Wolburg
Institutions: University of Bern, University of Tübingen
Language: English
Subfield: Immunology and Allergy
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2017830994