Prostate cancer regulatory networks
Year: 2009
Type: article
Abstract: Although the timing with which common epithelial malignancies arise and become established remains a matter of debate, it is clear that by the time they are detected these tumors harbor hundreds of deregulated, aberrantly expressed or mutated genes. This enormous complexity poses formidable challenges to identify gene pathways that are drivers of tumorigenesis, potentially suitable for therapeutic intervention. An alternative approach is to consider cancer pathways as interconnected networks, and search for potential nodal proteins capable of connecting multiple signaling networks of tumor maintenance. We have modeled this approach in advanced prostate cancer, a condition with current limited therapeutic options. We propose that the integration of three signaling networks, including chaperone-mediated mitochondrial homeostasis, integrin-dependent cell signaling, and Runx2-regulated gene expression in the metastatic bone microenvironment plays a critical role in prostate cancer maintenance, and offers novel options for molecular therapy.
Source: Journal of Cellular Biochemistry
DOI: 10.1002/jcb.22162
Institution: University of Massachusetts Chan Medical School
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1190947309, Control of Apoptosis in Cancer by Survivin, G1380587656, G1465312180, MOLECULAR PATHOLOGY OF VASCULAR INJURY, G218502673, G2540241349, G3407932214, G4130811054, Integrin Signaling Pathways in Prostate Cancer, G474305202, Beta1 Integrins and IGF-l Receptor in Prostate Cancer, G639853707, G652557304, G7047910, G8402550087, G865461561
OpenAlex ID: W2017881185