Work

Deuterium NMR tissue perfusion measurements using the tracer uptake approach: II. comparison with microspheres in tumors

Year: 1999

Type: article

Abstract: Whole-volume tumor perfusion measured using nuclear magnetic resonance (NMR) observation of deuterated water uptake after intravenous injection and a common arterial input function (AIF) derived from AIF estimates in a small set of animals was compared with perfusion measured by the commonly used microsphere method in rat 9L gliosarcomas. Tumor perfusion estimated with this optimized NMR technique using an appropriate common AIF (i.e., taking into account the duration of anesthesia) correlates highly (n = 13, P = 0. 001) with that measured by the microsphere method, yielding no significant differences (P = 0.5, paired Student's t-test). Thus, the optimized NMR method can be used for repeatable, non-invasive, and quantitative measurements of tumor perfusion. Magn Reson Med 42:240-247, 1999.

Source: Magnetic Resonance in Medicine

DOI: 10.1002/(sici)1522-2594(199908)42:2<240::aid-mrm5>3.0.co;2-8

Authors: Nicholas E. Simpson, Jeffrey L. Evelhoch

Institutions: Wayne State University, The Barbara Ann Karmanos Cancer Institute

Language: English

Topic: Advanced MRI Techniques and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Cancer Institute