35‐year‐old patient with chronic myelogenous leukemia developing systemic lupus erythematosus after α‐interferon therapy
Year: 1992
Type: article
Study design: Case Report
Abstract: The maculopapular rash recurred in December 1990, associated with fever, severe arthralgias, and headaches.Alpha-interferon was discontinued out of concern that it may be exacerbating the patient's condition.She was admitted to the University of Chicago in January 1991 for evaluation of worsening rash and fever.On physical examination, her temperature was 38.2"C.A blanching maculopapular rash was present over the malar areas of her face, trunk, and limbs.Upper extremity lesions were concentrated over the elbows.Musculoskeletal examination revealed tenderness and swelling of metacatpophalangeal joints bilaterally.The rest of her physical examination was normal except for splenomegaly, which was unchanged.Laboratory examination revealed a hematocrit of 35.4%; white count was 7,900 with 93% polys, 4% bands, and 1 % lymphocytes.Liver function abnormalities included an alkaline phosphatase of 246 (normal: 33-13 1 IU) and a SGOT of 40 IU (normal <35).An anti-nuclear antibody was elevated at 200 (nl 0-50) with a speckled pattern, double stranded DNA titer was
Source: American Journal of Hematology
Institution: University of Chicago
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2017962785