Work

Presence and formation of codeine and morphine in the rat.

Year: 1986

Type: article

Abstract: Endogenous codeine and morphine were identified in rat brain by immunological determination following HPLC. To demonstrate occurrence of a biosynthetic pathway to morphine in mammals similar to that used by the poppy plant, (+)-salutaridine, (-)-thebaine, and (-)-codeine were administered to rats intravenously. These compounds, which are intermediates in the synthesis of morphine in Papaver somniferum, caused a marked increase in the codeine and morphine levels in rat tissues. This provides evidence for a biosynthetic pathway to morphine in mammalians.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.83.12.4566

Authors: J Donnerer, K Oka, A Brossi, K C Rice, S Spector

Language: English

Topic: Neuropeptides and Animal Physiology

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2017974580

FWCI: 2.928

Cites: 10

Cited by: 139

Related to: 10