Work

Multi-colour fluorescence imaging in connection with photodynamic therapy of δ-amino levulinic acid (ALA) sensitised skin malignancies

Year: 1995

Type: article

Abstract: A system for multi-colour fluorescence imaging of tissue is described. The instrument is mainly developed for tissue diagnostics to identify and localise malignant tumours, but might also be useful for real-time monitoring of the therapeutic dose delivered during photodynamic therapy. In vivo examples from various malignant skin lesions following topical δ-amino levulinic acid (ALA) administration are presented. The diagnostic system utilises both characteristics of a fluorescent tumour marker, such as a porphyrin containing substance, and the native tissue autofluorescence to characterise the tissue. A dimensionless function of three or four simultaneously recorded fluorescence intensities is formed and an optimum-contrast image is calculated pixel-by-pixel.

Source: Bioimaging

DOI: 10.1002/1361-6374(199509)3:3<134::aid-bio4>3.0.co;2-1

Authors: Stefan Andersson-Engels, Roger Berg, Katarina Svanberg, Sune Svanberg

Institutions: Lund University, Skåne University Hospital

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Cancerfonden, Knut och Alice Wallenbergs Stiftelse