Treatment of Early and Established Cryptococcus neoformans Infection with Radiolabeled Antibodies in Immunocompetent Mice
Year: 2011
Type: article
Abstract: We investigated the utility of radioimmunotherapy (RIT) in early and established cryptococcal infection in immunocompetent mice. RIT with (213)Bi-18B7 antibody completely eliminated fungus from mouse lungs and brains for early infection, while (188)Re-18B7 significantly reduced CFU in the lungs or both lungs and brains during early and established infection, respectively. The results point to the independence of RIT of the immune status of the host, which is encouraging for translation of this strategy into the clinic.
DOI: 10.1128/aac.00473-11
Authors: Zewei Jiang, Ruth A. Bryan, Alfred Morgenstern, Frank Bruchertseifer, Arturo Casadevall, Ekaterina Dadachova
Institutions: Albert Einstein College of Medicine, Joint Research Centre
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1948673602, G2225302221, G2436179761, Synergy of Host Defense Mechanisms in the Lung, G2737691582, G2773611754, G4559384, G4617214234, G5683267944, G620796728, Protective antibodies for Cryptococcal Infections, G6928497940, Biology of Fungal Melanin, G7479519539, G813456599, Molecular Characterization of C. neoformans Antibodies
OpenAlex ID: W2018109745