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Time to Initiation of Antiretroviral Therapy Among Patients With HIV-Associated Tuberculosis in Cape Town, South Africa

Year: 2011
Type: article
Study design: Observational Study
Abstract: We studied the time interval between starting tuberculosis treatment and commencing antiretroviral treatment (ART) in HIV-infected patients (n = 1433; median CD4 count 71 cells per microliter, interquartile range: 32-132) attending 3 South African township ART services between 2002 and 2008. The overall median delay was 2.66 months (interquartile range: 1.58-4.17). In adjusted analyses, delays varied between treatment sites but were shorter for patients with lower CD4 counts and those treated in more recent calendar years. During the most recent period (2007-2008), 4.7%, 19.7%, and 51.1% of patients started ART within 2, 4, and 8 weeks of tuberculosis treatment, respectively. Operational barriers must be tackled to permit further acceleration of ART initiation as recommended by 2010 WHO ART guidelines.
DOI: 10.1097/qai.0b013e3182199ee9
Authors: Stephen D Lawn, Lucy Campbell, Richard Kaplan, Andrew Boulle, Morna Cornell, Bernhard Kerschberger, Carl Morrow, Francesca Little, Matthias Egger, Robin Wood
Institutions: University of Cape Town, London School of Hygiene & Tropical Medicine, Institute of Infectious Disease and Molecular Medicine, Médecins Sans Frontières, University of Bern, Institute of Social and Preventive Medicine
Language: English
Field: Medicine
Open Access status: green
Awards: G1350915675, G1645475817, G257683885, G4790657961, G596821015, Intensified tuberculosis case finding and rapid detection of drug resistant disease in patients accessing antiretroviral treatment in South Africa., G7004110296
OpenAlex ID: W2018179591
FWCI: 3.801
Cites: 18
Cited by: 31
Related to: 10